Trouble begins when Ratchet and Clank, now retired from saving the galaxy, are invited to an awards ceremony alongside Captain Qwark. Ratchet and Clank suspect something is up with the ceremony and would just as soon not go, yet Qwark - never one to shy from the spotlight - convinces the duo to accept. Quicker than you can say, "It's a trap," Dr. Nefarious springs his poorly conceived plot, unleashing a giant monster on the two heroes (and Qwark). The monster is enough to attract the attention of the Creature Collector, a machine collecting specimens for an intergalactic zoo.
If the four want to escape, they'll need to work together...