Graphics are better than adequate. Wisteria Lane is fairly fully realized, with white picket fences, houses of different design with lots of curb appeal, and fairly well-detailed characters. The five leading characters all resemble quite well the women of the TV show -- so much so, in fact, that I have to assume publisher Buena Vista Games had to pay handsomely for the right to use the actresses' images. The game is 3D, with a 360-degree in-game camera; occasionally when the camera passes awkwardly through a tree (like they do) you can see the somewhat poorly rendered leaves, but this minor shortcoming doesn't draw anything away from the game's sense of space. On the whole, Desperate Housewives is a satisfying graphical experience.
Audio is essentially as satisfying as the graphics; all of the musical score for the game comes from the TV show soundtrack. The voices, however, do not: with the exception of Brenda Strong, who is the voice of Mary Alice Young in both the show and the game, none of the actresses provide their voice talent. Nonetheless, the voice performances are plausibly representative. But I am neither desperate nor a housewife. For that matter, I am not a regular viewer of the show. Hardcore fans of the TV series may find themselves disappointed not to hear their favorite (or most hated) character sound, well, not quite right. Still, Brenda Strong does a splendid job with the cutscene voice work.
And fans will be interested to know that Scott Sanford Tobis, writer of the TV episode "Could I Leave You?" that aired in March, wrote the script for Desperate Housewives: The Game. Tobis puts together more than 21,000 lines of incredibly juicy dialogue for the game that fans of the show will no doubt appreciate.