Last year, I played Crash of the Titans on the PS2. So needless to say, the graphics are much improved in Mind Over Mutant. The characters are still cartoonish like they've always been, and I still think that's a good thing. I like the simplistic graphic nature of the game. If you want, you can even change Crash's clothing. The monsters are very varied in nature. They range from the big hulking things from last game to some new ones that float and fight using telepathy. The cut scenes to me were the funniest. They used quite a few different artistic methods including shadow puppets.
If you've ever played a Crash game before, then you know what everything sounds like. The voices have pretty much been constant for years now. Crash still speaks very little. My personal favorite is Aku-Aku (Greg Eagles). You might recognize his voice as the same actor who speaks for Grim in The Grim Adventures of Billy and Mandy.