The graphics are both good and bad in this game. The mini-pictures that show in the bottom corner of all the staff members are good. They're basically real images cartoonized. However, the characters themselves are very scary, especially George O'Malley. They remind me of characters from quite a few years ago when games were still trying to figure out how to make characters look too real and they just end up looking scary, much like the characters from American Idol: Karaoke Revolution for the 360. During the game, the pictures and level of detail was pretty well done. Granted, the body parts were very simplistic, but the x-rays where you have to find anomalies looked like real x-rays.
The background music is the Grey's Anatomy theme music from Season One. It'd be really nice if the characters from the show did the voices, but I'm guessing that would have cost more money than anyone spends on a game. So you don't get any voices, instead you read the text to get the full story unfolded.